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Anticoagulants: Phenobarbital lowers the plasma levels of dicumarol (name Beforehand utilised: bishydroxycoumarin) and causes a reduce in anticoagulant exercise as measured because of the prothrombin time. Barbiturates can induce hepatic microsomal enzymes leading to amplified metabolism and lowered anticoagulant reaction of oral anticoagulants (e.